Myeloproliferative neoplasm with eosinophilia and T-lymphoblastic lymphoma with ETV6–LYN gene fusion

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Myeloproliferative neoplasm with eosinophilia and T-lymphoblastic lymphoma with ETV6–LYN gene fusion

Myeloproliferative neoplasm with eosinophilia and T-lymphoblastic 1 lymphoma with ETV6-LYN gene fusion shows in vitro sensitivity to the 2 tyrosine kinase inhibitor dasatinib.

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A myeloproliferative neoplasm with translocation t(8;9)(p22;p24) involving JAK2 gene.

A 35-year-old male presented with a several-weeks history of abdominal discomfort, early satiety, low-grade fever, night sweats, and weight loss. Physical examination revealed pale skin and a massive hepatosplenomegaly. A complete blood count showed severe anemia, thrombocytopenia, and marked leukocytosis (100 000/mL) with 10% blasts, eosinophilia (4000/mL), and basophilia (3000/mL). Peripheral...

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[Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1].

The 2008 World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues introduced a new category for myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1. Many of these cases present as a myeloproliferative neoplasm, usually with eosinophilia. However, neoplasms associated with rearrangement of PDGFRA can present as acute...

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Concomitant diagnosis of myeloproliferative neoplasm and non-Hodgkin's lymphoma in a patient with portal vein thrombosis.

We describe here the rare coexistence, at the time of diagnosis, of a myeloproliferative neoplasm (MPN) and non-Hodgkin's lymphoma (NHL) in a 74-year-old patient who presented with thrombocytosis and signs of portal hypertension on physical examination. Abdominal computed tomography scan demonstrated extensive portal vein system thrombosis. Secondary causes of thrombocytosis were excluded. JAK2...

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ژورنال

عنوان ژورنال: Blood Cancer Journal

سال: 2016

ISSN: 2044-5385

DOI: 10.1038/bcj.2016.11